Psychophysiology of Delayed Extinction and Reconsolidation in Humans
Abstract
Animal research suggests that reactivation (retrieval) of a consolidated memory can return it to a labile state from which it must be restabilized in order to persist. This stabilization process has been termed reconsolidation , and various behavioral and pharmacological interventions have been found to modify or block it. The aim of this project is to create an experimental assay in the form of an optimal Pavlovian differential fear-conditioning paradigm, within which the relative strengths of various pharmacological and behavioral, reconsolidation-blocking interventions can be tested. Thus far, we have completed the testing for the pharmacological intervention group and are continuing the recruitment for the behavioral intervention group. Data from the pharmacological group demonstrate that participants show differential conditioning learning on Day 1, supporting the validity of our modified fear-conditioning paradigm. Results suggest that propranolol administration at the time of memory reactivation does not decrease the fear memory, as indexed by skin conductance, when assessing renewal and reinstatement. When looking at spontaneous recovery at Day 30, results suggest the emergence of a latent effect, which remains to be confirmed and understood better. The addition of a placebo control group is needed to make a conclusive statement about the efficacy of propranolol.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2013
- Accession Number
- ADA599323
Entities
People
- Scott P. Orr
Organizations
- Massachusetts General Hospital