Early Diagnosis of Clear Cell Kidney Cancer via VHL/HIF Pathway-regulated Circulating microRNA

Abstract

The over-arching objective of this research project is to identify a panel of diagnostic miRNAs that are measurable in the serum and will be able to identify kidney cancer in its earliest stages. We hypothesized that serum levels of miR-210 would be significantly elevated in patients with clear cell renal carcinoma and that a panel of serum miRNAs could be defined and optimized for use as a diagnostic tool in patients presenting with a renal mass. To achieve this objective, we proposed three specific aims to test our hypotheses, Institutional IRB approvals have been obtained (specific aim 1 task 1). Retrospectively collected samples have been transferred and analyzed (specific aim 1 task 3). Milestones are on track and we do not anticipate any alterations to our SOW.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA599473

Entities

People

  • Allan Pantuck

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Availability
  • Biomedical Research
  • California
  • Classification
  • Contracts
  • Department Of Defense
  • Hypotheses
  • Information Operations
  • Instructions
  • Kidney Cancer
  • Maryland
  • Monitoring
  • Security
  • Universities

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Oncology and Biomarker-Based Cancer Detection.