Inhibition of Pancreatic Cancer Cell Proliferation by LRH-1 Inhibitors
Abstract
The diagnosis of pancreatic cancer is devastating, with mortality rates nearing its incidence rates. To date, there are no effective targeted anti-pancreatic cancer therapeutics. We propose experiments that will explore function of an essential regulator of pancreatic development, the nuclear receptor LRH-1, in pancreatic cancer cells. Our target protein, LRH-1 receptor, is known to control not just one but multiple regulatory mechanisms essential for tumor growth and spread. We propose to find selective and potent compounds that inhibit LRH-1 activity in human pancreatic cancer cells, blunting their growth, proliferation and spread. The identified novel inhibitors of LRH-1 could then be developed into a pharmaceutical that will inhibit growth and proliferation of cancer cells in pancreatic tumors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2013
- Accession Number
- ADA599687
Entities
People
- Robert J. Fletterick
Organizations
- University of California, San Francisco School of Medicine