Development of Intake Retention, and Excretion Fractions used in Bioassay Programs for Metallic Nanoparticle Aerosols Produced in Modern Munitions Development
Abstract
The current state-of-the-art munitions development by the United States Air Force creates potential exposure scenarios wherein soldiers and laboratory workers may inhale nano-phase aerosols. The primary metals of present interest in this study are aluminum, boron, tantalum, titanium, and tungsten. The contained work describes efforts made to develop a software package capable of analyzing, and predicting, bioassay measurements of workers and soldiers following exposures to the metallic aerosols. The resultant software package (chemIMBA) developed by Dr. Alan Birchall of Public Health England was created by tailoring a pre-existing software package for radioactive aerosol exposures called, Integrated Modules for Bioassay Analysis (IMBA). Biokinetic model selection, and implementation, was conducted for boron, tantalum, titanium, and tungsten. For aluminum, a new systemic biokinetic model was created, and implemented within chemIMBA. Exposures to three different post-detonation blast-aerosols for open air, and enclosed environment scenarios for laboratory workers were simulated using the newly developed chemIMBA software. Intake Excretion Fractions, and Intake Retention Fractions, for time periods up to ten thousand days post-exposure were predicted for exposure scenarios of soldiers and laboratory workers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2014
- Accession Number
- ADA599900
Entities
People
- Charles M. Jenkins
- Wesley Bolch
- William Godwin
Organizations
- University of Florida