A Label-Free and Chemical-Selective Microendoscope to Enhance Prostate Cancer Surgical Outcomes
Abstract
Positive surgical margins after radical prostatectomy can increase the risk of disease recurrence, and the preservation of erectile function depends on identification and careful preservation of the neurovascular bundles. Coherent anti-Stokes Raman scattering (CARS) is a powerful imaging modality with label-free and chemically selective imaging ability. Our group is pioneering the development of a miniaturized fiber-based CARS system to assist label-free differentiation of prostate tissues and cavernous nerves (CNs) during robotic-assisted radical prostatectomy. We have completed the design of a handheld CARS microendoscope probe which includes a customized micro-electromechanical systems (MEMS) scanning mirror as well as miniature optical and mechanical components. The microendoscope probe is currently in the phase of completing the fabrication. The transversal diameter of the probe is 14 mm which is the smallest among all reported CARS microendoscope probes. We have performed Monte Carlo simulation and are expecting 1 m resolution for the CARS microendoscope probe system. To further improve the efficiency of laser delivery and signal collection for the fiber-based CARS system, we have tested the performance of fiber bundles in 6 and 18-multimode fiber configurations as well as single fiber. We have shown the feasibility of fiber-based systems by successful imaging of polystyrene beads and ex vivo tissue samples.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA600022
Entities
People
- Stephen T. Wong
- Xi Wang
- Xiaoyun Xu
- Xu Chen
- Zachary Satira
- Zhengfan Liu
Organizations
- Houston Methodist Research Institute