Shock Wave-Stimulated Periosteum for Cartilage Repair

Abstract

The primary objective of this project is to determine if extracorporeal shock wave (ESW)-stimulated periosteum improves cartilage repair when it is used as an autograft to fill a defect in the articular surface of goats. A miniature fiber optic pressure sensor will be inserted into the tibial periosteum of 6 animals to measure the actual shock waveform in the tissue for two ESW doses (energy densities). In 12 goats, tibial periosteum stimulated by one of the 2 doses of ESWs (n=6) will be harvested, 4 days post-treatment, as an autograft for implantation into one 1 cm2 defect surgically produced in the trochlear groove of the knee joint of the same goat. Non-ESW-treated periosteum will serve as the control group (n=6). All animals will be sacrificed after 16 weeks, and the reparative tissue will be quantified histomorphometrically by determining the areal percentage of selected tissues in the original cartilage defect area.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2013
Accession Number
ADA600597

Entities

People

  • Hu-ping Hsu
  • Myron Spector

Organizations

  • Boston VA Research Institute

Tags

Communities of Interest

  • Biomedical
  • Weapons Technologies

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Antigens
  • Autografts
  • Biological Staining And Labeling
  • Cartilage
  • Cells
  • Chemical Industry
  • Department Of Defense
  • Implantation
  • Monomolecular Films
  • Shock
  • Shock Waves
  • Stem Cells
  • Three Dimensional
  • Tissues
  • Waveforms
  • Waves

Readers

  • Trauma Surgery or Emergency Medicine.