Early Detection of Heterotopic Ossification for Effective Prevention and Treatment

Abstract

Heterotopic ossification (HO) is a pathological condition where soft tissues, such as muscles, calcify. Clinically, there are several forms of HO. Relevant to orthopaedic traumatology is HO that occurs in elbow and hip as a complication of injury, burn, brain injury or surgery. The prevalence of HO in wartime extremity injuries, particularly after amputation, is as high as 64%. HO can be painful and impair the motions and functions of prostheses and the affected extremities. Prophylactic radiation and medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) are effective, but these measures are not without serious side-effects and may be impractical for wartime injuries.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2014
Accession Number
ADA600600

Entities

People

  • Zijun Zhang

Tags

DTIC Thesaurus Topics

  • Brain Injuries
  • Cells
  • Detection
  • Gene Expression
  • Health Services
  • Heterotopic Ossification
  • Medical Personnel
  • Osteogenesis
  • Peptide Growth Factors
  • Stem Cells
  • Surgery

Fields of Study

  • Medicine

Readers

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