Targeting Prostate Cancer Stem-Like Cells Through Cell Surface-Expressed GRP78

Abstract

This study investigates a function for cell surface GRP78 in regulating prostate cancer stem-like cells. We investigate the hypothesis that cell surface GRP78 drives cancer stem-like behavior by activating an Akt/GSK-3/Snail-1 signaling axis in prostate cancer stem-like cells. In Aim 2, we study the ability of GRP78-neutralizing monoclonal antibodies to eliminate prostate cancer stem-like cells in vitro and in a mouse model. These studies have the potential to identify a novel and effective therapy for prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA601082

Entities

People

  • Salvatore Pizzo

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Anti-Bacterial Agents
  • Antibodies
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Chemotherapy
  • Culture Techniques
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Targeting
  • Terminals
  • Tissue Culture
  • Tissues

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).