A Novel Multivoxel-Based Quantitation of Metabolites and Lipids Noninvasively Combined with Diffusion-Weighted Imaging in Breast Cancer
Abstract
To extend the single-voxel based 2D MRS version of L-COSY to multi-voxel based analogue on a 3T MRI/MRS scanner using the echo-planar imaging (EPI) based spatial encoding for determining metabolic distributions over many voxels, ii) To implement a Matlab-based post-processing algorithm in order to process the 2D COSY data recorded in breast cancer, iii) To record DWI and to calculate ADC maps in breast cancer patients and healthy controls, and iv) To correlate the changes in metabolite and lipid levels with ADC changes in breast cancer patients and healthy women. Scope: A major outcome will demonstrate improving the specificity of malignant and benign tumors . Improved imaging techniques will enable unambiguous measurement of metabolites and the lipids in situ, which could potentially complement the existing diagnostic modalities commonly used in breast carcinoma. Major Findings: The MR protocol including 4D EP-COSI and DWI-MRI was successfully evaluated in six healthy women, 3 benign and 4 malignant breast cancer patients on a 3T MRI scanner. Report of the Progress: 4D EP-COSI and DWI-MRI were recorded in 13 subjects:4 malignant and 3 benign breast cancer patients and 6 healthy women. The EP-COSI data showed water and lipid/metabolite changes with DWI images showing reduced ADC values in suspicious lesions of breast cancer patients compared to healthy women.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA601642
Entities
People
- Michael A Thomas
Organizations
- University of California Regents