Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells

Abstract

Our proposal is to explore the novel notion that it may be possible to restore near normal HR activity in Brca1 cells and tissues. We believe that this phenomenon will lead to targeted therapies to reduce lifetime risk of tumor formation in BRCA1 and potentially BRCA2 carriers.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2014
Accession Number
ADA601775

Entities

People

  • Andre Nussenzweig

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chromosomes
  • Computational Biology
  • Fungi
  • Genetics
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Metabolic Diseases
  • Proteins
  • Skin Diseases
  • Stem Cells

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and genetic basis of cancer.