Development of Magnetic Resonance Imaging Biomarkers for Traumatic Brain Injury
Abstract
The purpose of this research program is to develop an imaging-based protocol to improve diagnosis and outcome prediction of mild traumatic brain injury (mTBI). Our major findings over the last year include: First, we have demonstrated that these new advanced MRI methods nicely complement conventional imaging methods in their ability to detect mTBI in the acute setting. Second, susceptibility weighted imaging and mapping (SWIM) are able to delineate venous structures and microbleeds making it possible to quantify and monitor evolution of pathological changes. Third, we have continued to use DTI data to look for local variations in ADC and FA values to assess tissue damage. And fourth, we have begun to accelerate the data collect process in patients with added support in both Radiology and Emergency medicine for both volunteers and mTBI patients. The significance of this work to date is that we are now able to find evidence of damage in mTBI where that has heretofore been difficult with conventional MRI. Keywords: Mild traumatic brain injury, susceptibility weighted imaging and mapping, temporal nature of TBI recovery, medullary vein damage.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2013
- Accession Number
- ADA601794
Entities
People
- E. M. Haacke
Organizations
- Wayne State University