Development and Testing of Iron Based Phantoms as Standards for the Diagnosis of Microbleeds and Oxygen Saturation with Applications in Dementia, Stroke, and Traumatic Brain Injury
Abstract
Our first goal is to establish a standard protocol with accurate methods for the magnetic susceptibility quantifications of materials in straws that are further inserted in agar gel phantoms. In this first year, we have measured magnetic susceptibility values of four different concentrations of each of the following materials in distilled water from multiple echo gradient echo MR images: nanoparticles, gadolinium, calcium, and ferritin. We have used a high-pass filter, a quadratic fit program, a SHARP method, and our own algorithm to remove the background phase from each image. The SHARP method seems to be a reasonably good method, as the uncertainty resulted from the combined usages of SHARP and our CISSCO method is about 10% of each quantified susceptibility value. Our own algorithm in combination with the CISSCO method also leads to accurate susceptibility quantification. However, given the measured susceptibility based on phase distributions outside each straw, except for gadolinium solutions, the phase value inside each straw is usually at least 10% away from the expected value. As we know the uncertainty of each of our measurement, even a 10% deviation deserves our attention and will be important for the MRI community to be aware of these unexpected findings. We are trying to understand the causes. As a comparison, we have also measured the concentrations of nanoparticle and gadolinium solutions with ICP-AES.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA601806
Entities
People
- Yu-chung N. Cheng
Organizations
- Wayne State University