Xenon as a Neuroprotectant in Traumatic Brain Injury

Abstract

The purpose of this novel study is to determine if xenon has a neuroprotectant effect in an vivo animal models of TBI. The project scope is an early proof of concept in rat models of xenon neuroprotection. The Specific Aims are to determine the effect of inhaled xenon on brain histopathology, behavior, in short- and long-term fluid percussion (FP) and controlled cortical impact (CCI) rat models of TBI compared to controls. The scope of this project is proof of concept in a rat model. Major findings and progress: We developed a recirculation xenon device for this project. Xenon and devices for behavioral studies acquired. IACUC and VA Research Approvals had been obtained. We believed ACURO approval was in place, but discovered late that it was not. We halted animal work immediately, and re-designed and submitted the appended Statement of Work, which was approved. Animal work generated without ACURO approval cannot be used. ACURO approval will be needed prior to starting this work.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2011
Accession Number
ADA601955

Entities

People

  • Jussi Saukkonen

Organizations

  • Boston VA Research Institute

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Brain Injuries
  • Department Of Defense
  • Electronic Mail
  • Governments
  • Histopathology
  • Information Operations
  • Maryland
  • National Governments

Readers

  • Clinical Trial Research.
  • Toxicology/Environmental Toxicology
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.