IL-6 Receptor Isoforms and Ovarian Cancer
Abstract
During the transition research period, we have purchased and are in the process of generating colonies of mice containing an IL6 Receptor (IL6R) knockout, liver and myeloid specific deletions of IL6R, and colonies with appropriate control mice. We have obtained and are generating the in house breeding colonies and have initiated measures for genotyping and increasing the numbers of experimental mice. Our goal is to generate these colonies of mice to complete experiments outlined in Specific Aim 2 related to determining the relative contributions of host IL6R to angiogenesis, cell survival and host survival of cancer cell lines in vivo.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2011
- Accession Number
- ADA601956
Entities
People
- Susan E. Waltz
Organizations
- University of Cincinnati