Assessment of Nanobiotechnology-Targeted siRNA Designed to inhibit NF-kappaB Classical and Alternative Signaling in Breast Tumor Macrophages

Abstract

Macrophages have been proposed as a potential target for manipulation of the microenvironment in breast cancer because they are potent effectors of the immune system. NF-kappaB (NF-kB) signaling in macrophages contributes to their impact during breast tumorigenesis. Thus, macrophage-targeted modulation of NF-kappaB has potential as a novel therapeutic approach for breast cancer. NF-kappaB signaling is mediated via two major pathways, the canonical/classical pathway and the alternative pathway.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2013
Accession Number
ADA601998

Entities

People

  • Fiona E. Yull
  • Ryan Ortega

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Materials Science
  • Medical Personnel
  • Polymer Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.
  • Immunology and Pathology

Technology Areas

  • Biotechnology