Regulation of mTOR by Nutrients
Abstract
The major functional of the TSC1 and TSC2 tumor suppressor genes is to inhibit the activity of the mammalian target of rapamycin (mTOR), which is a key cell growth regulator. mTOR forms two distinct physical and functional complexes, TORC1 and TORC2. Constitutive TORC1 activation contributes to tuberous sclerosis development. TORC1 is regulated by a wide range signals, including growth factors, cell energy levels, and nutrients. Amino acids are the most potent TORC1 activators, however the molecular mechanism of amino acid signaling to TORC1 activation is largely unknown. Recent works from our laboratory have identified the Rag GTPases in relaying amino acid signals to mTOR. We have showed the importance of Rag GTPases in TORC1 regulation and its relationship with the Rheb GTPase. Moreover, we have generated data support the Rab family GTPases in TORC1 regulation. These data provide new insights into the mechanism of TORC1 activation by amino acid signals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2010
- Accession Number
- ADA602038
Entities
People
- Kun-liang Guan
Organizations
- University of California, San Diego