Imaging Molecular Signatures of Breast Cancer with X-ray-Activated Nanophosphors
Abstract
This research program developed the foundation for Radioluminescence Imaging (RLI) and Radioluminescence Tomography (RLT) as new imaging tools for breast cancer screening and therapy monitoring. Numerous milestones were met including the development of reconstruction theory for RLI, the implementation of a software reconstruction for creating molecular images from both simulated and experimental data, instrumentation development, and demonstration of RLI in a small animal imaging cancer model. In dong so, aims 1-4 have been completed, and RLI endoscopic and full body (small animal) scanners remain as shared-resources for future ongoing research. Arising from this endeavour are several recommendations for successful research in RLI: phosphor brightness is paramount to successful imaging, as phosphors were tested that varied in light output by 3-4 orders of magnitude; control of ambient light is also paramount, and light-tight boxes are essential; multiplexing is straightforward with RLI, as emission peaks can be less than 15nm, however proper filtering is required; excitation source is very flexible, with radionuclides, x-ray sources, linear accelerators providing sufficient fluence for imaging, however, non-specific background luminescence is a confounder when very bright sources are used. In total, this project generated 12 journal publications, including 4 first author (2 more under consideration), 20 conference abstracts, and 4 courses taken. Several postdoctoral fellows are now being mentored and are working on RLI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2014
- Accession Number
- ADA602055
Entities
People
- Colin M. Carpenter
Organizations
- Stanford University