Mathematical Models of Human Hematopoiesis Following Acute Radiation Exposure

Abstract

This report details the development of mathematical models that describe the effects of acute radiation exposure on hematopoiesis. The models were developed from an existing structure and modified so that they could be integrated with effects on hematopoiesis from other injuries, such as thermal burns. Experimental data provided insight on many model parameters; other parameters were fit to case study data. The final models were validated against additional case study data. The outcome of our work are models that describe the dose response of circulating platelets, granulocytes, and lymphocytes as a function of time after irradiation. The information provided is valuable in understanding the physiological effects of radiation exposure and the time course of these effects.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2014
Accession Number
ADA602115

Entities

People

  • Daniela Stricklin
  • Darren Oldson
  • Jacqueline Wentz

Organizations

  • Applied Research Associates (United States)

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Transfusions
  • Bone Marrow Cells
  • Burns
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Computational Science
  • Gamma Rays
  • Granulocytes
  • Hematopoiesis
  • Hemorrhage
  • Lymphocytes
  • Monte Carlo Method
  • Radiation Sickness
  • Stem Cells
  • Therapy

Readers

  • Immunology and Pathology
  • Theoretical Analysis.