Technologies for Hemostasis and Stabilization of the Acute Traumatic Wound
Abstract
The purpose of this research is to advance hemostasis technology, and to develop effective hemostatic devices for two difficult types of hemorrhage: (1) traumatic noncompressible (also known as truncal) hemorrhage; and (2) traumatic hemorrhage in the cold coagulopathic subject. The scope of this research will include both military and civilian trauma victims, particularly those suffering from hemorrhagic truncal injury and/or coagulopathic hemorrhage, from both penetrating and blunt mechanism. During the first year of this project, we successfully generated stocks of two vitally important clotting factors (fibrinogen and Factor XIII), which we will need for the development and manufacture of our hemostatic devices. In addition, we developed prototypical methods to deliver foaming technology for the treatment of noncompressible hemorrhage, and created iterations of resorbable synthetic gauze for use as hemostatic bandages. We also generated preliminary preclinical data using both the noncompressible and the cold coagulopathic hemorrhage models (both in swine), and are positioned to perform extensive testing during the next year of the project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA602118
Entities
People
- Gustavo Larsen
- Luis Nunez
- Mark A. Carlson
- William H. Velander
- Wilson H. Burgess
Organizations
- University of Nebraska Omaha