Design and Synthesis of Bifunctional Oxime Reactivators of OP- inhibited Cholinesterase
Abstract
Organophosphorous (OP) cholinesterase inhibitors remain a significant threat to military and civilian personnel. Reactivators of OP inhibited cholinesterases can serve as OP agent antidotes but can be limited by their poor bioavailability and poor reactivation kinetics. New reactivator designs may be able to address these shortcomings. This proposal explores and evaluates the feasibly of synthesizing two new classes of oxime reactivators that use bifunctional catalysis to enhance kinetics and improve bioavailability. The synthesis of amino-functionalized aryltrifulorketoxmines and 3-alkylaminopyridinium oximes are described.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2013
- Accession Number
- ADA602407
Entities
People
- John T. Koh
Organizations
- University of Delaware