Transportable Life Support for Treatment of Acute Lung Failure Due to Smoke Inhalation and Burns

Abstract

This proposal compares 3 currently marketed extracorporeal gas exchange (ECGE) devices as means to treat lung failure. Objective: assess the capacity of the Hemolung, Cardiohelp and PECLA to lower injurious ventilator settings during transport of combat casualties with lung failure. Hypothesis: when used in conjunction with mechanical ventilation respiratory therapy with the Hemolung, or Cardiohelp, or PECLA permits a 50% or more reduction in minute ventilation. Specific aims: 1) Compare therapeutic efficiency of each ECGE device to reduce minute ventilation in model of ARDS due to smoke inhalation and burns in swine; 2) compare gas exchange efficiency and benchmark the ECGE devices; 3) compare expression of local (lung) and systemic inflammatory mediators; 4) assess safety of ECGE devices. Study design: prospective randomized study in 40 animals (10 for each device/group and controls).

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2014
Accession Number
ADA602417

Entities

People

  • Andriy I. Batchinsky

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acute Respiratory Distress Syndrome
  • Afghanistan Conflict
  • Airway Management
  • Carbon Dioxide
  • Casualties
  • Efficiency
  • Iraqi-War
  • Lung Diseases
  • Military Operations
  • Oxygenation
  • Patient Care
  • Respiration
  • Therapy
  • Transportable
  • Ventilation
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Trauma or Military Medicine