Assessing Vascular Oxygen Dynamics for Breast Tumor Prognosis: Comparison Between MR BOLD and Near Infrared Method
Abstract
The objective of this study is to investigate vascular oxygen dynamics in breast tumors by correlating the results of NIRS and of the BOLD method. In the research, we wish to utilize the NIR technique for a better understanding of the BOLD method in order to improve its clinical use as a diagnostic and/or prognostic tool for breast cancer research and clinical practice. We have proposed two hypotheses and three aims, as follows: Hypothesis 1: Three-channel NIRS combined with a fiber optical needle can provide spatial information of hemoglobin saturation (SO2) and concentration (Hb) of breast tumors during intervention. Hypothesis 2: Contrast agents in breast tumors based on the BOLD effect can be used to monitor variation in tumor oxygenation. Aim 1: To investigate heterogeneity of SO2 in the tumor vascular bed of breast tumors, using a three-channel NIR system against the fiber optic needle measurements. Aim 2: To compare and correlate the measurement results of the breast tumors under 100% O2 intervention taken simultaneously from the three-channel NIR oximeter and from the BOLD method. Aim 3: To study the influence of several respiratory interventions on SO2 and BOLD signals of breast tumors using both the three-channel NIR oximeter and the MRI BOLD method.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2005
- Accession Number
- ADA602456
Entities
People
- Hanli Liu
- Yuequing Gu
Organizations
- University of Texas at Arlington