Synthesis of the Insecticide Prothrin and Its Analogues from Biomass-Derived 5-(Cloromethyl)furfural

Abstract

Prothrin, a synthetic pyrethroid insecticide, was synthesized from the biomass-derived platform chemical 5- (chloromethyl)furfural in six steps and overall 65% yield. Two structural analogues of prothrin were also prepared following the same synthetic approach. Preliminary testing of these furan-based pyrethroids against the yellow fever mosquito Aedes aegypti indicates promising insecticidal activities.

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Document Details

Document Type
Technical Report
Publication Date
Dec 19, 2013
Accession Number
ADA602738

Entities

People

  • Alden S. Estep
  • Fei Chang
  • James John Becnel
  • Mark Mascal
  • Saikat Dutta

Organizations

  • Navy Entomology Center of Excellence

Tags

DTIC Thesaurus Topics

  • Acetylenes
  • Alcohols
  • Alkynes
  • Analogs
  • Chemical Synthesis
  • Chemistry
  • Chlorides
  • Environmental Protection
  • Food
  • Insecticides
  • Organic Chemistry
  • Pesticides
  • Platforms
  • Resmethrin
  • United States
  • Yellow Fever

Readers

  • Systems Analysis and Design
  • Vector-Borne Disease and Entomology