Improving PTSD Outcomes in OIF/OEF Returnees: A Randomized Clinical Trial of Hydrocortisone Augmentation of Prolonged Exposure Therapy

Abstract

To examine longitudinally, biological and psychological alterations in veterans with PTSD. Scope: To obtain a range of symptom severity over time, we will manipulate symptoms using two conditions: Prolonged Exposure (PE), and Minimal Attention (MA). The study will address the extent to which factors hypothesized to be associated with risk, symptom severity, and recovery have differing correlates by examining several biological and psychological variables in veterans who do and do not show recovery in response to PE, an intervention that alleviates PTSD symptoms in many subjects, compared to those in an MA condition. Epigenetic mechanisms associated with PTSD risk and recovery will also be considered. Major Findings: IC50 as predictor of treatment response, Methylation of the GR as predictor of clinical status.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2012
Accession Number
ADA603134

Entities

People

  • Rachel Yehuda

Tags

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Bioassay
  • Biological Markers
  • Biomedical Research
  • Blood
  • Chemistry
  • Clinical Trials
  • Cortisol
  • Department Of Defense
  • Diseases And Disorders
  • Health Services
  • Medical Personnel
  • Side Effects
  • Test And Evaluation
  • Therapy
  • Training
  • Traumatic Stress Disorder

Fields of Study

  • Psychology

Readers

  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.