Mapping the vasculome for biomarkers in TBI

Abstract

Mild-to-moderate TBI is the signature injury of US military personnel. Thus, there is an urgent need to find biomarkers for mildto- moderate TBI. In this proposal, our plan was to develop a vasculome database for TBI brain. By mapping the vasculome (i.e. entire gene expression profile in blood vessels) using mouse models of TBI, we will generate a comprehensive database that can be mined by the research community for potentially novel biomarkers of TBI. In this annual report, we describe our progress for the first year of our research, i.e. completion of all in vivo TBI mouse models, measurement of neurological deficits in all TBI mice, and the isolation of TBI microvessels and mRNA extraction.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA603162

Entities

People

  • Eng H. Lo

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • Blood
  • Blood Vessels
  • Brain Injuries
  • Cells
  • Communities
  • Databases
  • Gene Expression
  • Health Services
  • Medical Personnel
  • Microvessels
  • Military Personnel
  • Neurosciences
  • Protein-Protein Interactions

Readers

  • Distributed Systems and Data Platform Development
  • Oncology and Biomarker-Based Cancer Detection.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.