Integrative Lifecourse and Genetic Analysis of Military Working Dogs
Abstract
The project during the past year accelerated when the CRADA's were executed. In the first two years, we optimized the primary genotyping and molecular methods, and the follow-on validation methods. We also expanded the capabilities of our highly-flexible DAPER database and software tools in the present reporting year. To digitize the pathological records, we initiated the high through-put software customization (ABBYY FlexiCapture) for analysis of 1829 longitudinal veterinary records and AFIP/JPC pathological records. In addition, we have initiated the DoD military dog pathology reports to identify cancer bearing dogs for cancer classification and selection of cases and controls. In the first year we invented an entirely novel approach to conducting genome wide genetic association (GWA) analysis genomewide IUT analysis (GIA); and in the second year we further validated it. In this second reporting year, we integrated IUT and Bootstrapping as an additional innovation with outstanding utility. Dr. Alvarez s presentation of these methods and results to leaders in the fields of genetics and canine genetics resulted in uniformly positive feedback from them (and multiple requests for collaboration). In addition, Dr. Huang has developed the LDPMap algorithm for enabling accurate query of biomedical terms in the database. In addition, we co-authored (Alvarez) a published study that was not based on the present military dog project, but which made use of the same data mining and analysis methods that will be used in our study. The LDPMap algorithm paper is accepted to BMC Medical Genomics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA603168
Entities
People
- Kun Huang
Organizations
- Ohio State University