Epigenetic Testing for Breast Cancer Risk Stratification

Abstract

Tumor suppressor gene methylation is an early step-wise change in benign breast epithelium undergoing neoplastic transformation. Preliminary studies suggest that quantification of DNA methylation in benign random perareolar fine needle aspiration (RP-FNA) samples may provide a marker of breast cancer risk. We assessed the technical performance characteristics of QM-MSP in RP-FNA using an 11-marker panel and performed a case control study that included 31 breast cancer patients and 130 community-based controls. Though DNA methylation does provide a modest risk signal, high inter-assay variability and poor reproducibility make it unattractive for clinical risk stratification in its current form.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2014
Accession Number
ADA603859

Entities

People

  • David Euhus
  • Rolf Brekken

Organizations

  • University of Texas at Dallas

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkenes
  • Biomedical Research
  • Biopsy
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Communities
  • Corporations
  • Department Of Defense
  • Epithelial Cells
  • Epithelium
  • Gene Expression
  • Neoplasms
  • Oncology
  • Storage

Readers

  • Molecular and genetic basis of cancer.
  • Systems Analysis and Design