Expression of Proteins Involved in Epithelial-Mesenchymal Transition as Predictors of Metastasis and Survival in Breast Cancer Patients

Abstract

The purpose of this research is to investigate protein expression and promoter region DNA methylation status of six genes involved in epithelial-mesenchymal transition in relation to breast cancer lymph node metastasis, recurrence, and survival. Breast tumor tissue has been retrospectively identified from the Pathology Resource and immunohistochemical staining for all proteins has been completed. Scoring and analysis of IHC assays is ongoing. FFPE tissue cores for a subset of the IHC-stained tissues have been procured for isolation of DNA and methylation assay.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2013
Accession Number
ADA603895

Entities

People

  • Austin Miller
  • Christine Ambrosone
  • Gokul Das
  • Jo L Freudenheim
  • Michael Higgins
  • Michelle Roberts
  • Wiam Bshara

Organizations

  • Health Research, Incorporated

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Diseases And Disorders
  • Drug Therapy
  • Education
  • Electronic Mail
  • Epidemiology
  • Genes
  • Genetic Variation
  • Genetics
  • Lymph Nodes
  • Lymphatic System
  • Medical Personnel
  • Metastasis
  • Methylation
  • Neoplasms
  • Survival

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Oncology and Biomarker-Based Cancer Detection.