Nanog, Cancer Stem Cells, and Resistance to Chemotherapy
Abstract
Resistance to chemotherapy presents challenges to prostate cancer management. Preliminary data suggest that Nanog is associated with prostate cancer stem cells and Nanog may cause resistance toward chemotherapy. The objective of this proposal is to define the role of Nanog in resistance of prostate cancer cells toward chemotherapy, to determine whether Nanog can be targeted to sensitize tumor cells toward chemotherapy, and to identify the downstream effectors,especially a family of efflux transporters, called, ATP-binding cassette transporters, in Nanog-mediated chemoresistance. Various molecular, cellular, and pharmacological approaches will be employed to achieve the goals of the proposed studies. The proposed studies will validate whether we can target tumor Nanog to sensitize prostate cancer stem cells toward chemotherapy so that tumor recurrence or drug resistance can be eliminated. By performing and achieving the goals of the proposed research, the principal investigator will learn how to conduct cutting edge research that can be of high significance in the translational cancer research.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2014
- Accession Number
- ADA603912
Entities
People
- Hongmei Jiang
Organizations
- Southern Illinois University