Using Mode of Action to Assess Health Risks from Mixtures of Chemical/Physical Agents

Abstract

Interactions between carcinogens in mixtures found in the environment have been a concern for several decades. While interactions between initiators have received some attention, evaluations between tumor promoters with differing mechanisms of action have not been examined. In the present study, male B6C3Fl mice were used to study the responses to mixtures of dichloroacetate (DCA), trichloroacetate (TCA), and carbon tetrachloride (CT), each of which acts by a different mode of action. Mice were initiated by vinyl carbamate (VC), and then promoted by DCA, TCA, CT, or the pair-wised combinations of the three compounds. The effect of each treatment or treatment combination on tumor number/animal and tumor size was individually assessed.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2002
Accession Number
ADA604011

Entities

People

  • Lyle Sasser
  • Richard Bull
  • Xingye Lei

Organizations

  • Pacific Northwest National Laboratory

Tags

DTIC Thesaurus Topics

  • Additives (Chemicals)
  • Alkenes
  • Cancer
  • Carbon Tetrachloride
  • Carcinogens
  • Cells
  • Department Of Defense
  • Drinking Water
  • Hazardous Waste
  • Insulin
  • Metabolism
  • Neoplasms
  • Risk
  • Risk Analysis
  • Statistical Analysis
  • Water
  • Watercraft

Readers

  • Polymer Science and Engineering.
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology