Glutamate Signaling and Mitochondrial Dysfunction in Models of Parkinson's Disease

Abstract

The central hypothesis of the proposal is that in the early stages of PD, an elevation in synaptically released glutamate leads to persistent activation of NMDARs that synergizes with Cav1 calcium channels to significantly increase mitochondrial oxidant stress and neurodegeneration.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2014
Accession Number
ADA604089

Entities

People

  • D. James Surmeier

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Brain
  • Cells
  • Cellular Structures
  • Diseases And Disorders
  • Dysfunction
  • Elevation
  • Endoplasmic Reticulum
  • Glutamates
  • Neurodegeneration
  • Neurons
  • Neurosciences
  • Parkinson'S Disease

Fields of Study

  • Biology
  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Neuroscience