Molecular and Cellular Mechanisms of Pressure Induced Ca2+-Mediated Impairments of the Central Nervous System

Abstract

Hyperbaric environments present many physiological challenges, especially affecting the lungs, hollow viscera and the nervous system. Under pressure, soft tissues of the body behave as a fluid and rapidly transmit any pressure applied against the surface of the body to the adjacent fluid compartments. This results in hydrostatic compression of the cerebral spinal fluid, cerebral circulation, and extracellular and intracellular fluid compartments of the mammalian CNS. Thus, practically every cell is exposed to the ambient pressure.

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Document Details

Document Type
Technical Report
Publication Date
Apr 09, 2014
Accession Number
ADA604627

Entities

People

  • Yoram Grossman

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Cells
  • Central Nervous System
  • Compression
  • Environment
  • Intracellular Fluid
  • Nervous System
  • Soft Tissues
  • Tissues

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Structural Dynamics.