Early Life Stress and Sleep Restriction as Risk Factors in PTSD: An Integrative Pre-Clinical Approach
Abstract
The project proposes a novel integrative preclinical approach to study risk factors for and neurobiology of post- traumatic stress and depression. Why risk factors? Most models of PTSD concentrate on what would constitute a trauma in the studied animals. However, as most people exposed to traumatic experiences do not develop PTSD, the exposure to the trauma is not a sufficient condition to induce PTSD. WE focus on both distal (Childhood adversities) and proximal (Sleep restriction) potential risk factors, with high relevance to soldiers. The primary aims of the project are thus. 1) To establish an effective animal model of PTSD that would take into consideration risk factors to the induction of trauma 2) To examine the role of sleep restriction as an immediate risk factor in PTSD 3) To establish the role of childhood adversity as a long-term risk factor in PTSD, particularly in association with sleep restriction 4) To develop the model as a platform for pharmacological testing of novel targets for drug development 5) As an additional aim once an effective animal model is established - to use in order to identify novel targets for drug development
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2014
- Accession Number
- ADA604795
Entities
People
- Gal Richter-levin
Organizations
- University of Haifa