Development of Biodegradable Zinc Oxide Nanowires Targeting Breast Cancer Metastasis

Abstract

Our objective is to develop a biodegradable ZnO nanomaterial platform (mainly focusing on the nanowire [NW] morphology) for efficient vasculature targeting of BCa metastasis, and to optimize its optical property and conjugation chemistry for non-invasive dual-modality tracking (PET and optical). The overarching hypothesis is that suitably functionalized ZnO NWs can have long circulation lifetime and efficient tumor targeting for future drug delivery applications in treating BCa metastasis. Specific Aims: Aim 1: To develop strongly fluorescent ZnO NWs with desired size and emission wavelength. Aim 2: To optimize the biocompatibility and integrin v 3 targeting efficacy of ZnO NWs in vitro. Aim 3: To optimize the BCa metastasis targeting efficacy of ZnO NWs in vivo.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA605275

Entities

People

  • Yunan Yang

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Angiogenesis
  • Antibodies
  • Biological Staining And Labeling
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Department Of Defense
  • Emission
  • Endothelial Cells
  • Integrins
  • Metastasis
  • Nanotechnology
  • Neoplasms
  • Physical Properties
  • Tissues

Fields of Study

  • Chemistry

Readers

  • Nanoscale Plasmonic Nanotechnology
  • Oncology (Cancer Research).