Immune Analysis of Brisbane and California H1N1 in Human Sera and the MIMIC System, and Correlating a H1N1 Pandemic Influenza Clinical Trial with a Clinical Trial in a Test Tube
Abstract
This project extended over a three year period and focused on the use of the MIMIC system to assess the immunogenicity/efficacy of commercial influenza vaccine and a plant-produced recombinant hemagglutin (HA) influenza vaccine, from the HA sequence of the pandemic A/California H1N1 strain, produced by the Fraunhofer Center for Molecular Biology. Initially the task was to evaluate Fraunhofer s vaccine for efficacy in vitro either formulated with adjuvant (alum) or with no adjuvant and to evaluate the cross-reactivity and A/California H1N1 strain. The second section of the project focused on the coupling of the MIMIC to a clinical trial involving the Fraunhofer antigen and a commercial vaccine and the characterization and comparison of the in vivo and in vitro responses.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 15, 2013
- Accession Number
- ADA606195
Entities
People
- Anatoly Kachurin
- Vaughan Wittman
- William L. Warren