In Vivo PET Imaging of Myelin Damage and Repair in the Spinal Cord
Abstract
During the first funding cycle, we have worked closely with Dr Wang to develop a series of animal models to assess the efficacy of the imaging compounds that he has developed to detect demyelination and remyelination in the intact brain and spinal cord. We have also begun to test the ability of the imaging probes to assay remyelination in response to potential therapeutic treatments. The key research accomplishments are highlighted below: 1. Design, synthesis and evaluation of coumarin-based molecular probes for imaging of myelination. (Wang et al, J. Med. Chem. 2011) 2. Longitudinal imaging of myelination using a near infra-red probe. (Wang et al, J. Neuroscience 2011) 3. Longitudinal [11C]CIC-PET Imaging in the spinal cord of a rat model of focal demyelination.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2013
- Accession Number
- ADA606294
Entities
People
- Robert H. Miller
Organizations
- Case Western Reserve University