Systematic Characterization of the Molecular Mechanisms That Regulate and Mediate Alternative Lengthening of Telomeres in Breast Carcinoma

Abstract

Alternative lengthening of telomeres (ALT) is a mechanism utilized by several cancer types to maintain telomeres. The aim of this project is to characterize the mechanisms that mediate and regulate ALT activity in breast cancer, by utilizing proteomic and genomic approaches to describe and perturb ALT+ cells. Gaining this knowledge on ALT activity can promote the development of novel treatment for ALT+ breast tumors, and patients with telomerase inhibitor resistant tumors, while having minimal non-desired effects on the normal cell population that typically has no ALT activity. Here, I report on my progress in profiling the global transcriptional patterns that differentially characterize ALT+ cells. I describe the analytical tools that I used to define an ALT-related gene signature, and my efforts to identify potential functional relationship to ALT activity.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2014
Accession Number
ADA607152

Entities

People

  • Yaara Zwang

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Biology
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosome Structures
  • Data Sets
  • Gene Expression
  • Genetics
  • Molecular Biology
  • Neoplasms
  • Small Molecules
  • Statistical Analysis
  • Therapy

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Housing Policy Studies in Military Families with Privatization and Telomerase Allowance Units, Multi-Family Housing, and Telomere Lengths.
  • Theoretical Analysis.

Technology Areas

  • Biotechnology