Prevention and Treament of Botulism

Abstract

Abstract Concerns regarding botulinum neurotoxins (BoNTs) as biowarfare and bioterrorist agents have generated interest in developing medical countermeasures for protection against the neurotoxins. Efforts have focused on improvements in the available vaccines and antisera and de novo discovery of pharmacological inhibitors of toxin action. This chapter reviews the various approaches taken to develop next-generation vaccines, antitoxins and pharmacological treatments against intoxication by the BoNTs. The historical progression, current status and future trends are described.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2014
Accession Number
ADA607344

Entities

People

  • Brian Molles
  • Edward Eitzen
  • George Oyler
  • Michael Adler
  • Nizamettin Gul

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Biological Products
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Enzyme Inhibitors
  • Health Services
  • Medical Personnel
  • Peripheral Nervous System

Fields of Study

  • Medicine

Readers

  • Microbial Pathology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology