Modulation of the Immune Response to Androgen Deprivation and Radiation Therapy for the Treatment of Prostate Cancer
Abstract
The role of B cells in the tumor progression is not fully understood. Recent studies have suggested that specifically in prostate cancer, B cells promote inflammation that causes faster progression towards castrate resistant prostate cancer, which is difficult to treat. We tested the immune effects of depleting B cells using an anti CD20 antibody in conjunction with castration, which is commonly used as neo-adjuvant therapy for radiation. CD20 depletion leads a shift in the tumor environment with an increase in CD8+ T cells. Both CD4+ and CD8+ T cells are more responsive to TCR stimulation. However, survival is not enhanced with CD20 depletion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2014
- Accession Number
- ADA607786
Entities
People
- Lisa Johnson
Organizations
- BC Cancer Agency