DNA Damage and Genetic Instability as Harbingers of Prostate Cancer

Abstract

Current diagnostic modalities are inadequate to reliably differentiate between aggressive and indolent forms of prostate cancer (PCa). A significant number of men receive potentially unnecessary treatment along with associated morbidities. Identification of novel risk factors will allow for more reliable early diagnosis of PCa. Defective sensors of DNA damage and the resulting genetic instability may be involved in the early development of PCa. The objective of this project is to determine if DNA damage and genetic instability are harbingers of PCa using prostate biopsy samples from men at high risk for this disease. I am happy to report that this project has been completed six months ahead of time and below are its final results.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2013
Accession Number
ADA607796

Entities

People

  • Amit Algotar

Organizations

  • University of Arizona

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Carcinoma
  • Data Analysis
  • Diseases And Disorders
  • Electronic Mail
  • Instability
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Prostate
  • Prostate Cancer
  • Public Health
  • Risk Factors
  • Statistical Analysis
  • Tissues
  • Universities

Readers

  • Molecular Genetics
  • Prostate Cancer Biology.
  • Systems Analysis and Design

Technology Areas

  • Biotechnology