New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release
Abstract
Post-traumatic epilepsy (PTE) is a major long-term complication of traumatic brain injuries (TBIs), which are often suffered by members of the Armed Forces. PTE usually develops within five years of a head injury, and it is often expressed as medically intractable hippocampal epilepsy. Although there are a variety of causes of traumatic epilepsy, the resulting chronic neurological condition is characterized by common features, including recurrent spontaneous seizures, neuronal damage, mesial temporal lobe epilepsy (MTLE) in ~30% of patients, and resistance to available anticonvulsant drugs. Therefore, it is of critical importance to develop novel models to study post-traumatic epilepsy in order to facilitate the discovery of new treatments.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2014
- Accession Number
- ADA608027
Entities
People
- Emilio R. Garrido Sanabria
Organizations
- University of Texas at Brownsville