Dietary Regulation of PTEN Signaling and Mammary Tumor Initiating Cells: Implications for Breast Cancer Prevention

Abstract

Mammary steam cells (MaSC) are required for tissue homeostatis and epithelial expansion during the development; however, dysregulatoon of MaSC self-renewal such as by Wnt1 overexpression leads to neoplastic transformation. To date, in vivo dietary regulation of MaSC and its relation to breast cancer has not been evaluated. Therefore, I proposed to investigate the effect of lifetime intake of soy protein (SPI) diet relative to the control casein (CAS) diet on mammary steam cell (MaSC) population and its correlation to tumor formation in MMTV-Wnt1-Transgenic female mice. TYumor incidence was lower in SPI fed Wnt1-Tg mice relative to those fed CAS (48.3% vs. 73.5%; p less 0.05).

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2012
Accession Number
ADA608509

Entities

People

  • Omar Rahal

Organizations

  • Arkansas Children's Hospital

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Confocal Microscopy
  • Department Of Defense
  • Epithelial Cells
  • Growth Factors
  • Health Services
  • Mammary Glands
  • Peptides
  • Plant Oils
  • Proteins
  • Stem Cells

Readers

  • Breast cancer cell signaling and growth regulation.
  • Exercise and Sports Science.
  • Geochemistry