Wnt/beta-Catenin, Foxa2, and CXCR4 Axis Controls Prostate Cancer Progression
Abstract
Wnt/beta-Catenin signaling and associated target genes are implicated in the establishment of bone metastasis and in the development of castration resistant prostate cancer. Our previous studies have shown that Foxa2 is a Wnt/beta-catenin target gene in prostates. Our preliminary study suggests a Wnt Foxa2 CXCR4 axis that is involved in PCa bone metastasis, and activation of this axis provides survival mechanisms for PCa cells following androgen deprivation. The hypothesis is that the Wnt/beta-catenin activation of Foxa2 and CXCR4 promotes progression to CRPCa and facilitates bone colonization by PCa cells, and that targeting this axis will provide a novel treatment for PCa bone metastasis and relapse after androgen ablation. In the past one year, our effort mainly focused on addressing if active Wnt/beta-Catenin signaling-induced expression of Foxa2 promotes castration resistant prostate cancer grow in vivo (task 1b); if Foxa2 is involved in the interaction of prostate cancer cells and bone microenvironment (task 2a); and if over-expression of Foxa2 facilitates prostate cancer growth in the bone and progression to castration resistance (task 2b).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2014
- Accession Number
- ADA609497
Entities
People
- Xiuping Yu
Organizations
- Vanderbilt University