Functional Characterization of a Novel Prostate-Specific Gene PrLZ in Prostate Cancer

Abstract

This proposal is focused on the illustration of PrLZ, a novel prostate-specific gene identified in our laboratory. In the first year of a three-year project, we have prepared most of the molecular constructs necessary for the proposed experiments. We have determined that over-expression of this protein indeed promotes accelerated growth of prostate cancer cells. The underlying mechanism seems to be through interaction with the 14-3-3 proteins, especially the 14- 3-3 protein. Progress made in these studies lays a solid basis for continued research of PrLZ, an important regulatory gene in prostate morphogenesis, and in the development of prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2006
Accession Number
ADA609546

Entities

People

  • Ruoxiang Wang

Organizations

  • Emory University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anatomy
  • Biomedical Research
  • Cell Line
  • Cells
  • Dna Sequence Analysis
  • Epithelial Cells
  • Functional Analysis
  • Hybrid Systems
  • Morphogenesis
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Sequences
  • Statistical Analysis
  • Transfection
  • Xenografts

Readers

  • International Journalism and Media Studies.
  • Molecular Biology and Genetics
  • Systems Analysis and Design