Comprehensive Population-Specific Marker Panel for Early Prostate Cancer Diagnostics and Risk Assessment
Abstract
The overall scope of the proposed postdoctoral training project is to provide protected time for the Primary Investigator (PI) to obtain a comprehensive training in the field of prostate cancer health disparity. The PI is a postdoctoral scientist whose long-term career goal is to contribute to the resolution of cancer-related health disparities by conducting innovative, high-impact research as an independent investigator. Within the scope of this grant, a comprehensive training consists of the two main parts: a training part and a research part. For the training part, PI is attending relevant seminars, conferences, takes classes, and writes manuscripts and grants. For the research part, we hypothesized that a combination panel (DETECT) of genetic, biochemical, socio-cultural and lifestyle populationspecific biomarkers and factors will provide a valuable PCa screening and risk assessment tool. The PI has started with the genotyping of 528 DNA samples obtained from African American and European American men with prostate cancer and controls. It was found that two SNPs were statistically significantly associated with prostate cancer risk in African American, and one SNP - in European American men. Going further, the excessive prostate cancer risk associated with one of the SNPs in African American men was found in obese men only; it was not seen in either non-obese African American men, or European American men regardless of their body mass. The PI has proposed a concept of the increased risk in obese AAM which will be functionally tested in the year 2 of this award.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2012
- Accession Number
- ADA609950
Entities
People
- Ganna Chornokur
Organizations
- H. Lee Moffitt Cancer Center & Research Institute