Evaluation of Multimodal Imaging Biomarkers of Prostate Cancer
Abstract
The goals of the proposed studies are to: i) use imaging methods to non-invasively assess the temporal relationship between castration resistant prostate cancer (CRPC) growth, androgen receptor (AR) levels, angiogenesis, hypoxia, and translocator protein (TSPO) levels and ii) use imaging to temporally direct pathological examination of tissue in order to enhance the elucidation of mechanistic aspects of CRPC progression, specifically the involvement of HIF-1alpha and NF-kappaB, two pathways that increase AR activity during progression to CRPC. As described in the statement of work, the second year of this award focused on starting the acquisition of serial imaging data in the Pten/p53 double null mutant mouse model. Towards that end, we have successfully acquired anatomic MRI and PET data in orthotopic tumors within the Pten/p53 mouse model, to assess tumor volume, track growth and tumor angiogenesis. In fic speciregards to PET imaging, we have further characterized the use of FMISO, FDHT and TSPO imaging to evaluate tumor hypoxia, androgen receptor levels and translocator protein expression. The characterization of these imaging features has better informed their use in serial studies aiming to assess these biological features before and after castration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2014
- Accession Number
- ADA610682
Entities
People
- Christopher C. Quarles
Organizations
- Vanderbilt University