Regulation of Mitochondria Function by TRAF3 in B Lymphocytes and B Cell Malignancies
Abstract
This project aims to investigate how a new tumor suppressor gene, TRAF3, regulates mitochondria function in B lymphocytes and B cell malignancies. TRAF3 deletions and mutations occur in a variety of B cell malignancies, including B cell chronic lymphocytic leukemia (B-CLL), non-Hodgkin lymphoma (NHL, such as splenic marginal zone lymphoma and mantle cell lymphoma), multiple myeloma (MM), and Waldenstr m s macroglobulinemia. We found that specific deletion of TRAF3 from B lymphocytes results in remarkably prolonged survival of mature B cells, which eventually leads to development of splenic marginal zone lymphoma or B1 lymphoma in mice. In this context, understanding how TRAF3 promotes B cell apoptosis is critical for rational design of therapeutic intervention of human B cell neoplasms. In pursuing such underlying mechanisms, we have obtained an unexpected but highly interesting finding.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2014
- Accession Number
- ADA610687
Entities
People
- Ping Xie
Organizations
- Rutgers University–New Brunswick