Evaluation of Diffusion Kurtosis Imaging in Traumatic Brain Injury

Abstract

The goal of this study is to identify novel imaging marker such as diffusion kurtosis that may serve as a prognostic marker in the evaluation and management of traumatic brain injury patients. This study will recruit patients patients with varying severity of traumatic brain injury (mild, moderate, severe) from the Shock Trauma center with an initial diagnosis of diffuse axonal injury. Neuropsychological testing and magnetic resonance imaging will be performed in the acute, sub-acute and chronic stages (through 6 months). The relationship between the advanced magnetic resonance imaging markers and the clinical condition of the patient will be evaluated at each time point to determine which of the imaging markers, or a combination of imaging markers are best representative of the clinical condition of the patient. Further, the markers will be evaluated for their prognostic ability to determine the clinical course of the TBI patients.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2013
Accession Number
ADA610706

Entities

People

  • Rao P. Gullapalli

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Acquisition
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Diffusion
  • Electrical Engineering
  • Health Services
  • Image Segmentation
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Maryland
  • Medical Personnel
  • Resonance
  • Shock Trauma Centers
  • Test And Evaluation

Fields of Study

  • Medicine

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Plasma Physics / Magnetohydrodynamics
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.