UNC Center for Dynamic Combinatorial Chemistry

Abstract

We have initiated our search for anion receptors using the hypothesis that the binding of complex anions (e.g. ATP, ADP, nitrotyrosine, phosphotyrosine, etc for these model studies), will require a domain for the binding of the more hydrophobic portion of the molecule (the nucleobase) and a domain for desolvating and subsequently binding the phosphate portion of the anion. To achieve this end we have designed monomers that will form a cavity to bind the organic portion of the organophosphates selectively while also providing electrostatic interactions to stabilize the phosphate anion. Disulfide exchange was selected as the reversible reaction to generate the library, as it is compatible with aqueous solution and is well established for DCC. In addition, we have developed thioester exchange as an alternative reversible reaction because it is significantly faster than disulfide exchange.

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Document Details

Document Type
Technical Report
Publication Date
Apr 09, 2014
Accession Number
ADA610855

Entities

People

  • Michel R Gagné

Organizations

  • University of North Carolina at Chapel Hill

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Abstracts
  • Acids
  • Agreements
  • Amines
  • Amino Acids
  • Anisotropy
  • Chemical Synthesis
  • Chemistry
  • Department Of Defense
  • Electrospray Ionization
  • Engineering
  • Mathematics
  • Molecules
  • Protein-Protein Interactions
  • Small Molecules
  • Students
  • Tyrosine

Fields of Study

  • Chemistry

Readers

  • Electrochemical Surface Science
  • Molecular and Cellular Biochemistry