Bone Repair and Military Readiness

Abstract

Even though commercial bone cements have not significantly changed in the past 50 years and have been used throughout the world, there are significant drawbacks with the current systems. We have developed a silorane based resin superior to polymethyl methacrylate (PMMA) with many improved properties such as significantly less polymerization stress without an associated reduction in mechanical properties. The specific aims for this project are: Specific Aim 1: Develop a silorane bone cement suitable for in vivo studies and to optimize the formulation of the chemically and mixed cured cement prototypes. Specific Aim 2: Determine the biocompatibility properties and wear debris generation of silorane bone cement prototype. Specific Aim 3: Determine the biological response to silorane bone cement prototype in animal models. By addressing the shortcomings of current PMMA bone cement, the development of the novel silorane bone cement will result in a paradigm shift in orthopedic biomaterials.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2014
Accession Number
ADA610970

Entities

People

  • David Eick
  • Lynda Bonewald

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anti-Bacterial Agents
  • Bone Marrow
  • Cell Line
  • Chemical Synthesis
  • Chemistry
  • Composite Materials
  • Department Of Defense
  • Growth Factors
  • Health Services
  • Infection
  • Joints (Anatomy)
  • Mechanical Properties
  • Osteogenesis
  • Particles
  • Prostheses And Implants
  • Prosthetics

Fields of Study

  • Materials science

Readers

  • Mechanical Engineering/Mechanics of Materials.
  • Nanocomposite Materials Science
  • Pavement Materials Engineering.